Fish scoring breast cancer

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These HER2 receptors receive signals that stimulate the growth of breast cancer cells. However, FISH is considered more accurate. Research has shown that some HER2 test results may be wrong. This is probably because different labs have different rules for classifying positive and negative HER2 status. Each pathologist also may use slightly different criteria to decide whether the results are positive or negative. In most cases, this happens when the test results are borderline -- meaning they aren't strongly HER2-positive or HER2-negative.
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Breast cancer IHC/ISH portfolio

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Fluorescence in Situ Hybridization (FISH) | CancerQuest

Breast Cancer Research and Treatment. While HER2 testing is well established in directing appropriate treatment for breast cancer, a small percentage of cases show equivocal results by immunohistochemistry IHC and fluorescence in situ hybridization FISH. Alternative probes may be used in equivocal cases. Most However, Because almost half of FISH equivocal cases converted to HER2 amplified upon alternative testing, clinical studies to determine the benefit of anti-HER2 therapy in these patients are urgently needed. Without anti-HER2 treatment, HER2 -amplified tumors are associated with poor prognosis [ 1 , 2 ], but when treated with therapies targeting HER2, such as trastuzumab, pertuzumab, and TDM-1, they are shown to markedly improve survival [ 3 , 4 , 5 ].
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FISH Test (Fluorescence In Situ Hybridization)

Beiyun Chen, M. Katherine Geiersbach, M. Did you know that 1 in 8 women in the United States will be diagnosed with breast cancer in her lifetime? Katherine Geiersbach and Dr. Thank you for that introduction.
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Working with our dedicated and highly trained Surgical Pathology Team at UR Medicine Labs means that you will receive quicker turnaround for results and personal attention to your cases. You can be assured that you are getting the best in clinical laboratory testing such as:. Proper results determine the course of therapy for Breast and Gastric Cancer patients. Figure 1 legend: Immunohistochemistry utilizes antibodies against HER2 to assess the level of protein expression at the membrane of invasive tumor cells in formalin fixed paraffin embedded sections DAKO Hercep Test, x original magnification. The interpretation of HER2 results must be semi-quantitatively evaluated in order to be useful for treatment planning.
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